by Zoltan P. Rona M.D., MSc
The leaky gut syndrome is the name given to a very common health disorder in which the basic organic defect (lesion) is an intestinal lining which is more permeable (porous) than normal. The abnormally large spaces present between the cells of the gut wall allow the entry of toxic material into the bloodstream that would, in healthier circumstances, be repelled and eliminated.
The gut becomes leaky in the sense that bacteria, fungi, parasites and their toxins, undigested protein, fat and waste normally not absorbed into the bloodstream in the healthy state, pass through a damaged, hyperpermeable, porous or “leaky” gut. This can be verified by special gut permeability urine tests, microscopic examination of the lining of the intestinal wall as well as the bloodstream with phase contrast or darkfield microscopy of living whole blood.
Why is The Leaky Gut Syndrome Important? The leaky gut syndrome is almost always associated with autoimmune disease and reversing autoimmune disease depends on healing the lining of the gastrointestinal tract. Any other treatment is just symptom suppression. An autoimmune disease is defined as one in which the immune system makes antibodies against its own tissues. Diseases in this category include lupus, alopecia areata, rheumatoid arthritis, polymyalgia rheumatica, multiple sclerosis, fibromyalgia, chronic fatigue syndrome, Sjogren’s syndrome, vitiligo, thyroiditis, vasculitis, Crohn’s disease, ulcerative colitis, urticaria (hives), diabetes and Raynaud’s disease. Physicians are increasingly recognizing the importance of the gastrointestinal tract in the development of allergic or autoimmune disease. Understanding the leaky gut phenomenon not only helps us see why allergies and autoimmune diseases develop but also helps us with safe and effective therapies to bring the body back into balance.
Due to the enlarged spaces between the cells of the gut wall, larger than usual protein molecules are absorbed before they have a chance to be completely broken down as occurs when the intestinal lining is intact. The immune system starts making antibodies against these larger molecules because it recognizes them as foreign, invading substances. The immune system starts treating them as if they had to be destroyed. Antibodies are made against these proteins derived from previously harmless foods.
Human tissues have antigenic sites very similar to those on foods, bacteria, parasites, candida or fungi. The antibodies created by the leaky gut phenomenon against these antigens can get into various tissues and trigger an inflammatory reaction when the corresponding food is consumed or the microbe is encountered. Autoantibodies are thus created and inflammation becomes chronic. If this inflammation occurs in a joint, autoimmune arthritis (rheumatoid arthritis) develops. If it occurs in the brain, myalgic encephalomyelitis (a.k.a. chronic fatigue syndrome) may be the result. If it occurs in the blood vessels, vasculitis (inflammation of the blood vessels) is the resulting autoimmune problem.
If the antibodies end up attacking the lining of the gut itself, the result may be colitis or Crohn’s disease. If it occurs in the lungs, asthma is triggered on a delayed basis every time the individual consumes the food which triggered the production of the antibodies in the first place. It is easy to see that practically any organ or body tissue can become affected by food allergies created by the leaky gut. Symptoms, especially those seen in conditions such as chronic fatigue syndrome, can be multiple and severely debilitating.
The inflammation that causes the leaky gut syndrome also damages the protective coating of antibodies of the IgA family normally present in a healthy gut. Since IgA helps us ward off infections, with leaky gut problems we become less resistant to viruses, bacteria, parasites and candida. These microbes are then able to invade the bloodstream and colonize almost any body tissue or organ. When this occurs in the gums, periodontal disease results. If it happens in the jaw, tooth extraction or root canals might be necessary to cure the infection.
In addition to the creation of food allergies by the leaky gut, the bloodstream is invaded by bacteria, fungi and parasites that, in the healthy state, would not penetrate the protective barrier of the gut. These microbes and their toxins, if present in large enough amounts, can overwhelm the liver’s ability to detoxify. This results in symptoms such as confusion, memory loss, brain fog or facial swelling when the individual is exposed to a perfume or to cigarette smoke that he or she had no adverse reactions to prior to the development of the leaky gut syndrome.
Leaky gut syndrome also creates a long list of mineral deficiencies because the various carrier proteins present in the gastrointestinal tract that are needed to transport minerals from the intestine to the blood are damaged by the inflammation process. For example, magnesium deficiency (low red blood cell magnesium) is quite a common finding in conditions like fibromyalgia despite a high magnesium intake through the diet and supplementation. If the carrier protein for magnesium is damaged, magnesium deficiency develops as a result of malabsorption. Muscle pain and spasms can occur as a result. Similarly, zinc deficiency due to malabsorption can result in hair loss or baldness as occurs in alopecia areata. Copper deficiency can occur in an identical way leading to high blood cholesterol levels and osteoarthritis. Further, bone problems develop as a result of the malabsorption of calcium, boron, silicon and manganese.
The leaky gut syndrome is basically caused by inflammation of the gut lining. This inflammation is usually brought about by the following:
The leaky gut syndrome can cause the malabsorption of many important micronutrients. The inflammatory process causes swelling (edema) and the presence of many noxious chemicals all of which can block the absorption of vitamins and essential amino acids. A leaky gut does not absorb nutrients properly. Bloating, gas and cramps occur as do a long list of vitamin and mineral deficiencies. Eventually, systemic complaints like fatigue, headaches, memory loss, poor concentration or irritability develop.
Prescription broad spectrum antibiotics, especially when taken for extended periods of time, wipe out all the gut friendly bacteria that provide protection against fungi and amoebic (parasitic) infections, help the body break down complex foods and synthesize vitamins like B12 and biotin. Since this friendly bowel flora is killed off, the body now has no local defence against the parasites or fungi that are normally held in check. This then causes an inflammatory reaction leading to the leaky gut syndrome. Food allergies quickly develop and these may trigger the signs and symptoms of arthritis, eczema, migraines, asthma or other forms of immune dysfunction. Other common symptoms of this bowel flora imbalance and leaky gut syndrome are bloating and gas after meals and alternating constipation with diarrhea. This set of symptoms is usually labelled as IBS (Irritable Bowel Syndrome) or spastic bowel disease and treated symptomatically by general practitioners and gastroenterologists with antispasmodic drugs, tranquilizers or different types of soluble (psyllium) and insoluble (bran) fiber.
The Leaky Gut and IBS
The mainstream thinking on IBS is that it is caused by stress. Irritable bowel syndrome is the number one reason for general practitioner referrals to specialists. In well over 80% of the cases, tests like the intestinal permeability test (a special urine test involving the determination of absorption rates of two sugars called lactulose and mannitol), CDSA or livecell darkfield microscopy reveal the presence of an overgrowth of fungi, parasites or pathogenic bacteria. The one-celled parasite, blastocystis hominis and different species of candida are the most common microbes seen in IBS. The only stress associated with IBS is that which is generated by infection and the leaky gut syndrome. If allowed to persist without the correct treatment, IBS can progress into more serious disorders like the candidiasis syndrome, multiple chemical sensitivities, chronic fatigue syndrome, many autoimmune diseases and even cancer. If treated medically, IBS is rarely cured. To treat it correctly, natural treatments work best and must include the removal of the cause, improvement of gastrointestinal function and healing the lining of the gut.
How to Reverse Leaky Gut Syndrome
Band-aid treatments with corticosteroids, prescription antibiotics and immuno suppressive drugs may be temporarily life-saving for acute episodes of pain, bleeding or severe inflammation as occurs in lupus or colitis. In the long run, however, none of these treatments do anything to heal the leaky gut problem. To reverse the leaky gut syndrome the diet must be completely changed to one which is as hypoallergenic as possible. Sugar, white flour products, all gluten-containing grains (especially wheat, barley, oats and rye), milk and dairy products, high fat foods, caffeine products, alcohol and hidden food allergies determined by testing must all be eliminated for long periods of time (several years in the most severe cases).
Treatment might also include the use of natural antibiotics (echinacea, colloidal silver, garlic), antiparasitics (cloves, wormwood, black walnut) and antifungals (taheebo, caprylic acid, grapefruit seed extract) depending on the type of infection which shows up on objective tests. It is rare that victims require prescription drugs for these infections and they should be discouraged. The drugs are usually expensive, have unpleasant side effects and are best reserved for life-threatening conditions.
Leaky gut syndrome patients can help themselves by chewing their food more thoroughly, following the basic rules of food combining, eating frequent small meals rather than three large ones and taking more time with their meals. Gastrointestinal function can be improved with a juice fast or a hypoallergenic diet and supplements like lactobacillus acidophilus and bifidus as well as FOS (fructooligosaccharides) derived from Jerusalem artichoke, chicory, the dahlia plant or burdock root.
Beneficial Supplements for Leaky Gut Syndrome Natural digestive enzymes – from plant (e,g, bromelain, papain) or pancreatic animal tissues (porcine, bovine, lamb) and aloe vera juice with a high MPS concentration (good brands are International Aloe, Earthnet and Royal) stomach acidity enhancing supplements – betaine and pepsin, glutamic acid, stomach bitters, apple cider vinegar amino acids – L-glutamine, N-acetyl-glucosamine (NAG) essential fatty acids – milled flax, flax seed oil, evening primrose oil, borage oil, olive oil, fish oils, black currant seed oil soluble fiber – psyllium seed husks and powder, apple or citrus pectin, the rice derived gamma oryzanol, antioxidants – carotenoids, B complex, vitamin C, E, zinc, selenium, germanium, Coenzyme Q10, bioflavonoids, especially quercetin, catechin, hesperidin, rutin and proanthocyanidins (pycnogenols, grape seed extract, pine bark extract, bilberry) herbs and plant extracts – kudzu, various high chlorophyll containing green drinks like spirulina, chlorella and blue green algae, burdock, slippery elm, Turkish rhubarb, sheep sorrel, licorice root, ginger root, goldenseal, bismuth and bentonite. Combination Green Foods – two excellent products are Green Life (Bioquest) and Greens Plus (Supplements Plus)
Due to the increasing recognition of chronic fatigue syndrome, the leaky gut syndrome and multiple chemical sensitivity, a number of supplement companies have been marketing powdered hypoallergenic formulations containing most of the nutrients mentioned above in one convenient package. Some brand names include Ultrabalance®, UltraClear Sustain®, UltraClear Plus®, Pro-Cleanse®, Pro-Support® and ActiClear®. The products are only available through natural health care practitioners like chiropractors, nutritional doctors and naturopaths. If you suspect you may be suffering from leaky gut syndrome, the most important thing to do is get yourself tested by a natural health care practitioner. A personalized natural program of diet and supplements can then be instituted to help you reverse this debilitating condition.
I love when I can help families heal health challenges naturally.
Often I will get moms or grandmothers in the store asking about how to treat infant oral thrush holistically.
My protocol is as follows:
This treatment protocol is about 90% effective. It is 100% effective if the mother also balances out her food regime (refined sugar free, low fructose, high vegetable (ideally juicing), high quality fat and carbohydrates).
There is no need for harsh, suppressive pharmaceuticals. Most parents notice once a drug is removed, the thrush simply returns with a vengeance and the immune system has been further compromised by it.
Primarily, it is wise to support the body naturally to help the innate healing abilities do their fine work. Suppressive medicine is there as the last ditch effort, not the first step.
We are in a intimate, inter-dynamic relationship with bacteria, they are not the enemy! We need to educate ourselves properly on this issue...
By Anthony Gucciardi
Contributing Writer for Wake Up World
Scientists are now confirming what many natural health advocates have been saying for years regarding the role bacteria plays in the body. Bacteria, and exposure to bacteria on a daily basis, is essential to a proper immune system. With many parents ensuring that their children are virtually never exposed to enough bacteria through sanitizing everything they touch with triclosan-containing antibacterial wipes and gels, children worldwide are not being exposed to an adequate amount of immune-bolstering bacteria in the environment.
Adults are also being effected, as many individuals feel that virtually all germs or bacteria are bad and make a large effort to scrub them from their daily life. The new research, which simply enforces what has been known for centuries, shows that problems can arise when your exposure to germs is decreased. In fact, it could make you sick. The concept is referred to as the ‘hygiene hypothesis’, which essentially says that diseases affect more individuals in the modern world where hygiene and mobile sanitizers are king.
The new study comes from the Women’s Hospital in Boston, and shows just how drastically bacteria exposure can affect the health of you and your entire family. Researchers examined two groups of mice with very different outcomes. The first group was exposed to a normal bacteria environment, while the second was completely germ-free. The scientists then compared the immune systems of both groups, finding evidence that powerfully demonstrates the importance of bacterial exposure.
Not only did the mice which were exposed to microbes have stronger immune systems than the germ-free mice, but the germ-free mice had significant inflammation in their lungs and colon — similar to asthma and ulcerative colitis in humans. One immune cell in particular, the invariant natural killer T cell, was particularly hyperactive as well.
“There is a very beneficial role for microbes in health,” senior study author Dr. Richard Blumberg said.
While it can be a challenge in modern society, it is important to allow yourself natural exposure to bacteria in the environment. Something known as ‘grounding’ may be particularly beneficial. Grounding is simply the practice of coming into contact with the earth while barefoot, which has been shown by peer-reviewed research to help remedy a number of conditions. It is also highly important to consume an adequate amount of probiotics in food or supplement form, also known as the ‘good bacteria‘. Fermented food items such as sauerkraut, tempeh, miso or kefir are all rich sources of probiotic bacteria.
UCC scientists have shown that brain levels of serotonin, the 'happy hormone' are regulated by the amount of bacteria in the gut during early life. Their research is being published June 12 in the international psychiatry journal, Molecular Psychiatry.
As well, an Italian study confirms this information stating that providing probiotics, or "good bacteria," to healthy infants shortly after they're born may reduce the development of gastrointestinal disorders and prolonged crying episodes later in life.
In the Italian study, newborns that received a daily dose of the probiotic Lactobacillus reuteri had fewer episodes of inconsolable crying (colic), constipation and regurgitation (reflux) at age three months compared to newborns given a placebo. Use of probiotics also had benefits in terms of reducing health care expenses, such as money spent on emergency department visits, or money lost when parents took time off work. On average, families with infants that took probiotics saved about $119 per child, the researchers said.
Scientists at the Alimentary Pharmabiotic Centre in UCC used a germ-free mouse model to show that the absence of bacteria during early life significantly affected serotonin concentrations in the brain in adulthood. The research also highlighted that the influence is sex dependent, with more marked effects in male compared with female animals. Finally, when the scientists colonized the animals with bacteria prior to adulthood, they found that many of the central nervous system changes, especially those related to serotonin, could not be reversed indicating a permanent imprinting of the effects of absence of gut flora on brain function.
"As a neuroscientist these findings are fascinating as they highlight the important role that gut bacteria play in the bidirectional communication between the gut and the brain, and opens up the intriguing opportunity of developing unique microbial-based strategies for treatment for brain disorders," said Professor John F Cryan, senior author on the publication and Head of the Department of Anatomy & Neuroscience at UCC.
This research has multiple health implications as it shows that manipulations of the microbiota (e.g. by antibiotics, diet, or infection) can have profound knock-on effects on brain function. "We're really excited by these findings" said lead author Dr Gerard Clarke. "Although we always believed that the microbiota was essential for our general health, our results also highlight how important our tiny friends are for our mental wellbeing."
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Amandha D. Vollmer
This creative mompreneur herbalist